orf2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G17887 (orf2) on chromosome 3 of Fusarium graminearum PH-1 encodes a cytochrome P450 monooxygenase, a membrane-associated oxidoreductase that binds iron and heme and acts on paired donors with incorporation of molecular oxygen. The gene is associated with mycotoxin anabolism, including aflatoxin, sterigmatocystin, and griseofulvin production, as well as secondary metabolite and terpenoid biosynthesis. It has also been linked to pigmentation, defense responses, and antiviral responses, including response to virus. Studies of related genes in other species connect the family to similar oxidoreductase functions, though these associations are not yet established in F. graminearum.