SEC22 — Fusarium graminearum PH-1

Summary

FgSEC22 (SEC22) on chromosome 3 of Fusarium graminearum PH-1 encodes a SNARE protein containing a Longin domain and a V-SNARE coiled-coil region. It is associated with vesicle fusion with the Golgi apparatus, ER-to-Golgi transport, cis-Golgi-to-rough-ER transport, membrane fusion, intracellular protein transport, autophagy, ER-phagy, and perithecium formation. The protein localizes to the ER membrane, Golgi membrane, COPII-coated vesicle membrane, ER exit site, and SNARE complex. Phenotypic associations include absent protein transport and vacuolar transport, decreased cell fusion and nuclear fusion during mating, abnormal Golgi and ER distribution, absent spore germination, decreased cell death, and altered cell cycle progression. Studies of related genes in other species link the family to reduced virulence and traits such as turgor pressure and protein content.