BEM1 — Fusarium graminearum PH-1

Summary

FgBEM1 (FGRAMPH1_01G17483) on chromosome 3 of Fusarium graminearum PH-1 encodes a protein containing SH3, PX, and PB1 domains characteristic of the Bem1/Scd2 family, with annotated molecular functions in phosphoinositide binding and protein binding, bridging. The gene is associated with regulation of conjugation with cellular fusion, cell polarization, and mating projection assembly. Phenotypic associations include absent mating efficiency, delayed nuclear fusion during mating, absent cell fusion, decreased spore germination, and abnormal pheromone production and sensitivity. Additional associations include decreased redox state, abnormal lifespan, and delayed protein secretion and transport. Related genes in other species are linked to reduced virulence and fusarium head blight, as well as oxidative stress response and acid sensitivity.