PP2A — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G17523 (PP2A, also known as PPG1) encodes a protein with protein phosphatase activity, protein serine/threonine phosphatase activity, O-glucosyl hydrolase activity, and metal binding, belonging to the PPA2-like and calcineurin-like phosphoprotein phosphatase families. In Fusarium graminearum, this gene is associated with protein dephosphorylation, regulation of cell shape, glycogen metabolism, regulation of TORC1 signaling, regulation of septation initiation network, regulation of cytoplasmic translation, and pachytene checkpoint. It localizes to the PP2A complex, protein phosphatase 4 complex, mitotic spindle pole body, chromatin, nuclear periphery, and mitochondrial outer membrane. The gene is linked to abnormal pheromone sensitivity, cell cycle progression, decreased apoptosis, increased mitophagy, decreased pexophagy, abnormal budding, decreased protein secretion, and decreased ionic stress resistance. Studies of related genes in other species link the family to reduced virulence and fusarium head blight.