SCS7 — Fusarium graminearum PH-1

Summary

FgSCS7 (FGRAMPH1_01G17255) on chromosome 3 of Fusarium graminearum PH-1 encodes a fatty acid hydroxylase with cytochrome b5-like heme/steroid-binding domains, possessing fatty acid 2-hydroxylase and sphingolipid C4-monooxygenase activities, along with electron transfer, iron, and heme binding. The gene is associated with MIPC biosynthesis, sphingolipid and ergosterol anabolism, fatty acid metabolism, sporulation, and hyphal growth, and localizes to the ER membrane and mitochondria. It is linked to decreased autophagy and pexophagy rates, delayed endocytosis and vacuolar transport, abnormal pseudohyphal growth and septum formation, increased freeze-thaw resistance, absent UV resistance and meiotic recombination, and altered cell cycle progression. Related genes in other species connect the family to ceramide hydroxylation and oxidative stress response.