ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (FGRAMPH1_01G17383) on chromosome 3 of Fusarium graminearum PH-1 encodes an ABC-type oligopeptide transporter with ATP hydrolase activity and ATP-coupled transmembrane transporter activity. The protein belongs to the type 1 exporter family and is localized to the mitochondrial inner membrane, plasma membrane, and membrane fractions. It is associated with oligopeptide export from mitochondria, sterol anabolism, secretion, membrane transport, and homeostasis. Phenotypic associations link the gene to altered cell cycle progression, including increased G2/M phase transition and entry into G0, decreased endocytosis, abnormal vacuolar and peroxisomal distribution, increased pexophagy, and reduced hyperosmotic and hypo-osmotic stress resistance. The gene is also connected to decreased fermentative metabolism and abnormal colony color. Related genes in other species link the family to mitochondrial peptide export.