NEO1 — Fusarium graminearum PH-1

Summary

FgNEO1 (FGRAMPH1_01G17221) on chromosome 3 of Fusarium graminearum PH-1 encodes a P-type ATPase with lysophosphatidylserine, glycoceramide, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine flippase and floppase activities, as well as potassium and sodium transporter activities. The gene is associated with phospholipid and ceramide translocation, endocytic recycling, post-Golgi transport, membrane fusion, endocytosis, vesicle transport, and establishment of cell polarity. It localizes to the trans-Golgi network membrane, endosome membrane, division septum, and mating projection tip membrane. Phenotypic associations include abnormal pseudohyphal growth, decreased shmoo formation, increased ionic stress and UV resistance, decreased nutrient uptake, altered cell cycle progression, and abnormal septum formation. Related genes in other species are linked to reduced virulence and associations with fusarium head blight and vascular wilt diseases.