RAB7 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G17199 (RAB7) in Fusarium graminearum PH-1 encodes a small GTPase with GTPase activity and GTP binding. This gene is associated with vacuole fusion, endosome organization, vesicle formation and fusion, Golgi-to-vacuole transport, exocytosis, and sexual reproduction. It is linked to regulation of vacuole fusion, response to carbon starvation, and cellular homeostasis. The protein localizes to endosomal and vacuolar membranes, the meiotic spindle pole body, and the endomembrane system. Phenotypic associations include altered vacuolar morphology, delayed autophagy and endocytosis, decreased cell death rate, increased hydrostatic pressure and alkaline pH resistance, and abnormal replicative lifespan and mitotic cell cycle. Related Rab7 family members in other species are linked to virulence and stress responses.