ENA1 — Fusarium graminearum PH-1

Summary

FgENA1 (FGRAMPH1_01G16639) on chromosome 3 of Fusarium graminearum PH-1 encodes a P-type ATPase of the IID subfamily with annotated potassium:proton transporter, sodium transporter, manganese transporter and calcium transporter activities, as well as ATP hydrolase activity and calcium ion binding. The gene is associated with potassium and sodium ion export from the cell, cellular pH regulation, manganese and calcium ion membrane transport, and responses to unfolded protein. It localises to the plasma membrane at cell tips, the medial membrane band, the nuclear envelope, vacuolar and Golgi membranes, and the ER membrane. Phenotypic associations include abnormal cell cycle progression, decreased endocytosis, increased anaerobic growth, increased ionic stress and freeze-thaw resistance, absent desiccation resistance, decreased necrotic cell death, and absent meiosis and nutrient uptake. Studies of related genes in other species link the family to sodium concentration, potassium content and virulence.