CI-1 — Fusarium graminearum PH-1

Summary

FgCI-1 (FGRAMPH1_01G16001) on chromosome 2 of Fusarium graminearum PH-1 encodes a cytochrome P450 monooxygenase with heme and iron binding, and oxidoreductase activity acting on paired donors with molecular oxygen incorporation. The gene is associated with ergosterol, paxilline, mycotoxin, terpenoid and secondary metabolism, and localises to membranes. It has been linked to numerous cellular and developmental phenotypes, including decreased colony size, vegetative growth arrest, increased cell death, abnormal plasma membrane and cytoskeleton morphology, defective endocytosis, vacuolar transport, autophagy, micronucleophagy, meiosis, cytokinesis, shmoo formation, mating response, and G2/M cell cycle arrest, as well as increased budding and fermentative growth, altered telomere length, mitochondrial distribution and genome maintenance, and petite formation. Related genes in other species are linked to potassium concentration and acid sensitivity.