PMR1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G15485 (PMR1) on chromosome 2 of Fusarium graminearum PH-1 encodes a P-type cation-transporting ATPase with multiple annotated transporter activities, including potassium:proton, sodium, manganese and calcium transport, as well as ATP hydrolase activity. The gene is associated with the export of potassium and sodium ions from the cell, cellular pH reduction and regulation, calcium and manganese ion membrane transport, and the release of sequestered calcium into the cytosol by the Golgi. It has also been connected to asexual reproduction and the response to unfolded protein. The encoded protein localises to the plasma membrane at the cell tip, the medial membrane band, the vacuolar membrane, the Golgi membrane, the nuclear envelope, lipid rafts and extracellular vesicles. Studies of related genes in other species link the family to reduced virulence.