ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (FGRAMPH1_01G15297) on chromosome 2 of Fusarium graminearum PH-1 encodes a protein with ligase activity and ATP binding. The gene is associated with sterol anabolism, secretion, and homeostasis. Phenotypic associations link FgABC2 to abnormal vacuolar morphology and distribution, increased pexophagy, decreased endocytosis, altered cell cycle progression (including increased G2/M phase transition and entry into G0), decreased fermentative metabolism, and abnormal colony color. It is also connected to abnormal nuclear export, and decreased endoplasmic reticulum distribution with increased Golgi distribution. Stress-related associations include absent hyperosmotic stress resistance and decreased hypoosmotic stress resistance, while oxidative stress resistance is normal. The gene is related to TLC1 and NFT1. Studies of related genes in other species link the family to ABC transporter function, and sequence similarity connects the family to leaf width and shape traits.