ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (FGRAMPH1_01G15041) on chromosome 2 of Fusarium graminearum PH-1 encodes an ABC-type transporter with ATP-binding and transmembrane domains, classified as an ABC-type oligopeptide and xenobiotic transporter with ATP-coupled transmembrane transporter activity. The gene is associated with oligopeptide export from mitochondria, response to antibiotics, xenobiotic detoxification across the plasma membrane, sterol anabolism, secretion, membrane transport, and homeostasis. The product localises to the fungal-type vacuole, mitochondrial inner membrane, and plasmalemma. Phenotypic associations include altered resistance to oxidative and osmotic stresses, abnormal vacuolar morphology and distribution, increased pexophagy, decreased endocytosis, abnormal cell cycle progression, and changes in colony colour, protein accumulation, and fermentative metabolism. The gene is also linked to related transporters such as TLC1, NFT1, and MDL1.