CID1 — Fusarium graminearum PH-1

Summary

FgCID1 (FGRAMPH1_01G14867) on chromosome 2 of Fusarium graminearum PH-1 encodes a protein with poly(U) polymerase activity, nucleotidyltransferase activity, UTP binding, ATP binding, and mRNA 3′-UTR binding. The protein contains PAP-associated and MTPAP-like central domains. It is associated with polyuridylation-dependent decapping and catabolism of nuclear-transcribed mRNA, negative regulation of poly(A) tail shortening, 3′-UTR-mediated mRNA stabilization, mitochondrial RNA catabolic process, siRNA catabolic processes, and RNA 3′ end processing. The gene is linked to pigmentation, sexual reproduction, hyphal growth, mycotoxin anabolism, secondary metabolism, and homeostasis. The product localizes to mitochondria, cytoplasm, cytosol, and nucleus. Studies of related genes in other species connect the family to polynucleotide adenylyltransferase activity (EC 2.7.7.52 and 2.7.7.19), though these functions are not established for FgCID1 itself.