laeA — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G14819, the Fusarium graminearum PH-1 gene laeA on chromosome 2, encodes a protein with a SAM-dependent methyltransferase domain and methyltransferase activity. The product localises to the nucleus and is associated with DNA-dependent transcription, methylation, and the regulation of secondary metabolism, including secondary metabolite biosynthesis and gliotoxin anabolism. It has been linked to ergosterol anabolism, spore formation, and disruption of host phagocytosis. Studies of related genes in other species connect the family to oxidative stress response and germination rate.