CP1 — Fusarium graminearum PH-1

Summary

FgCP1 (FGRAMPH1_01G14481) on chromosome 2 of Fusarium graminearum PH-1 encodes a serine carboxypeptidase belonging to the peptidase S10 and alpha/beta hydrolase families. The gene is associated with proteolysis, zymogen activation, vacuolar protein catabolism, Golgi-to-vacuole transport, sexual reproduction, secondary metabolism, and antibiotic anabolism. Its product localises to the fungal vacuole lumen, vacuolar membrane, and plasma membrane. FgCP1 has been linked to numerous phenotypes including altered cell death, abnormal autophagy, defective nuclear fusion during mating, increased aneuploidy, impaired protein secretion, and changes in prion inheritance, lifespan, and thermotolerance.