ABCA — Fusarium graminearum PH-1

Summary

FgABCA (FGRAMPH1_01G13949) on chromosome 2 of Fusarium graminearum PH-1 encodes an ABC transporter of the PDR/CDR subfamily, possessing ATP hydrolase and ATP-binding activities. The gene is associated with extracellular transport, detoxification, toxin anabolism, hypersensitivity, DNA repair, and seed germination. Its product localises to the plasma membrane. The gene is linked to abnormal small molecule transport, increased sporulation rate, altered vacuolar distribution and transport, decreased cell death rate, delayed exit from stationary phase, and abnormal pseudohyphal growth, bipolar budding, shmoo formation, cell cycle progression, and chronological and replicative lifespan. Related genes in other species connect the family to multidrug resistance.