ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (FGRAMPH1_01G13749) on chromosome 2 of Fusarium graminearum PH-1 encodes an ABC-type transporter with ATP hydrolase activity, belonging to the type 1 exporter family and containing ABC transporter-like ATP-binding and transmembrane domains. The gene is associated with multiple transport processes, including iron-sulfur cluster export from the mitochondrion, phytochelatin and cadmium ion import into the vacuole, and glutathione transport into the vacuole. It is linked to cellular detoxification of cadmium ions, iron-sulfur cluster assembly, cellular iron ion homeostasis, and sterol anabolism. The product localises to mitochondrial and vacuolar membranes. Associations with phenotypes include altered oxidative and hypoosmotic stress resistance, abnormal vacuolar morphology and distribution, decreased endocytosis rate, increased pexophagy, and abnormal cell cycle progression, including increased G2/M phase transition and entry into G0 stationary phase.