NPS6 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G13607 (NPS6, also known as SIDD or FgSIDD) on chromosome 2 of Fusarium graminearum PH-1 encodes a protein containing adenylation, condensation, and carrier domains characteristic of nonribosomal peptide synthetases, and is annotated with SAM-dependent methyltransferase, ligase, isomerase, and methyltransferase activities, as well as phosphopantetheine binding. The gene is associated with nonribosomal peptide and siderophore biosynthesis, specifically N',N'',N'''-triacetylfusarinine C production, as well as toxin and ergosterol biosynthesis, secondary metabolism, sexual reproduction, cellular response to iron starvation, and hypersensitivity. The encoded protein localizes to the cytoplasm. Related genes in other species are linked to reduced virulence and diseases including fusarium wilt, leaf blight, and brown spot.