PMG — Fusarium graminearum PH-1

Summary

FgPMG (FGRAMPH1_01G13733) on chromosome 2 of Fusarium graminearum PH-1 encodes a member of the APC/YAT family of amino acid permeases, possessing L-arginine and L-lysine transporter activity. The gene is associated with polyamine metabolism, SAM transport, and the regulation of nitrogen utilization, as well as filamentous growth. The encoded protein localizes to the plasma membrane at cell tips, the medial membrane band, Golgi, vacuole, and extracellular vesicles. Phenotypic associations include increased nutrient uptake and carbon source utilization, increased freeze-thaw and ionic stress resistance, decreased nitrogen source utilization, absent adhesion and hydrostatic pressure resistance, abnormal colony shape, and altered cell cycle progression, meiotic recombination, and endocytosis. Studies of related genes in other species link the family to calcium and acid sensitivity and oxidative stress response.