CI-1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G13463 (symbol CI-1, preferred name ERG5B) on chromosome 2 of Fusarium graminearum PH-1 encodes a cytochrome P450 family protein with C-22 sterol desaturase (NADPH) and sterol 14-demethylase activities, along with heme binding, iron binding, monooxygenase and oxidoreductase functions. The gene is associated with ergosterol and terpenoid biosynthesis, sterol metabolism, and filamentous growth in response to starvation or biotic stimuli. It localises to the endoplasmic reticulum membrane, perinuclear and cortical ER, and the plasma membrane. Associations include altered fermentative growth, endocytosis, vacuolar transport, cell cycle progression, cytokinesis, cell death, cytoskeleton and mitochondrial morphology, nutrient uptake, mating response, and vegetative growth. Studies of related genes in other species link the family to reduced virulence and fusarium head blight.