ERG4 — Fusarium graminearum PH-1

Summary

FgERG4 (FGRAMPH1_01G12897) on chromosome 2 of Fusarium graminearum PH-1 encodes a sterol reductase with D14-sterol reductase activity and NADP binding, belonging to the Sterol_reductase_CS and ERG24_DHCR-like families. The gene is associated with ergosterol and sterol anabolism, membrane transport, and cellular responses to xenobiotic stimuli, and its product localises to the endoplasmic reticulum membrane. Associations with numerous phenotypes include abnormal bipolar budding, decreased endocytosis, abnormal plasma membrane morphology, sterility, decreased cell fusion, absent or decreased pheromone-induced cell cycle arrest and shmoo formation, decreased mating response, arrested vegetative growth, decreased invasive and pseudohyphal growth, abnormal cell wall morphology, decreased cold sensitivity, decreased nutrient uptake and iron/phosphorus utilization, increased or absent cell death, abnormal cell cycle progression, abnormal cytoskeleton morphology, and decreased vacuolar transport. Related genes in other species link it to hydrogen peroxide content and acid sensitivity.