CI-1 — Fusarium graminearum PH-1

Summary

FgCI-1 (FGRAMPH1_01G12445) on chromosome 2 of Fusarium graminearum PH-1 encodes a cytochrome P450 monooxygenase with heme binding and iron binding activities, acting on paired donors with incorporation of molecular oxygen. The gene is associated with ergosterol, griseofulvin, mycophenolic acid, cichorine, and terpenoid anabolism, as well as secondary metabolite biosynthesis. Its product localizes to the endoplasmic reticulum membrane. Phenotypic associations include increased fermentative growth, decreased endocytosis, absent micronucleophagy, abnormal telomere length and plasma membrane morphology, absent vacuolar transport, decreased meiosis, abnormal autophagy, decreased shmoo formation and mating response, increased budding, absent protein secretion, decreased colony size and vegetative growth, arrested cell cycle progression, increased cell death, abnormal cytoskeleton and mitochondrial distribution, and decreased nutrient uptake. Related genes in other species link the family to potassium concentration and acid sensitivity.