cka — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G12499 (cka) on chromosome 2 of Fusarium graminearum PH-1 encodes a dual-specificity protein kinase with protein serine/threonine kinase activity, protein tyrosine kinase activity, and cyclin-dependent kinase (CDK) activity, and it belongs to the CK2 alpha catalytic subunit family. The gene product is associated with the casein kinase II complex, CDK holoenzyme, nucleolus, chromatin, division septum, and mitotic spindle pole body. It is associated with the regulation of mRNA splicing via the spliceosome, chromosome segregation, spindle assembly, mitotic cell cycle control, triglyceride catabolism, glycogenolysis, mycose catabolism, and telomere maintenance. Studies of related genes in other species link the family to reduced virulence and fusarium ear blight, though this has not been established for this specific gene.