CDC2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G12137 (CDC2) on chromosome 2 of Fusarium graminearum PH-1 encodes a cyclin-dependent kinase (CDK) with protein serine/threonine kinase activity, ATP binding, cyclin binding, RNA polymerase II core binding, and histone binding. The gene is associated with regulation of the mitotic cell cycle, including DNA replication, spindle elongation, chromosome attachment, and telomere tethering, as well as meiotic processes such as DNA double-strand break formation and linear element maturation. It is linked to negative regulation of primary cell septum biogenesis and anaphase-promoting complex-dependent catabolism, positive regulation of protein breakdown, glycogenolysis, and triglyceride catabolism, and regulation of cellular responses to glucose starvation and apical bud growth. The product localizes to CDK-cyclin complexes, meiotic and mitotic spindles, spindle pole bodies, and telomeric chromosome regions. Studies of related genes in other species link the family to pathogenicity and oxidative stress responses.