ABCA — Fusarium graminearum PH-1

Summary

FgABCA (FGRAMPH1_01G11505) on chromosome 2 of Fusarium graminearum PH-1 encodes an ABC transporter, possessing ATP-coupled transmembrane transporter activity and ATP hydrolase activity. The gene is associated with xenobiotic detoxification via transmembrane export across the plasma membrane, response to antibiotics, toxin anabolism, and DNA repair. It is linked to extracellular transport, seed germination, hypersensitivity, and detoxification processes. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death rate, altered vacuolar distribution and transport, delayed exit from G0, increased fermentative growth, and abnormal chronological and replicative lifespan. The protein localises to the plasma membrane. Studies of related genes in other species link the family to multidrug resistance, though these associations are not established for FgABCA itself.