HXK1 — Fusarium graminearum PH-1

Summary

FgHXK1 (FGRAMPH1_01G11851) on chromosome 2 of Fusarium graminearum PH-1 encodes a hexokinase with hexokinase, glucokinase, fructokinase, mannokinase and glucosamine kinase activities, and binds ATP and D-glucose. The protein localises to mitochondria and the cytosol. It is associated with glycolysis, glucose and fructose metabolism, fructose uptake, cell glucose homeostasis, mannose metabolism, and sexual reproduction. The gene is linked to numerous phenotypes including abnormal cell cycle progression through G1/S and G2/M, increased M phase rate, decreased mitotic recombination, increased anaerobic growth, decreased lifespan, absent desiccation resistance, increased freeze-thaw resistance, decreased entry into G0, decreased cell death, delayed metaphase-anaphase transition, altered endoplasmic reticulum and Golgi distribution, decreased prion inheritance, abnormal RNA modification, absent budding, decreased pexophagy, and absent silencing. Studies of related genes in other species link the family to biomass yield, alkali sensitivity, oxidative stress response, and reduced virulence.