ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (FGRAMPH1_01G11311) on chromosome 2 of Fusarium graminearum PH-1 encodes an ABC-type transporter with ATP hydrolase activity, belonging to the type 1 exporter family and containing ABC transporter-like ATP-binding and transmembrane domains. The gene is associated with oligopeptide export from the mitochondrion, xenobiotic detoxification via transmembrane export across the plasma membrane, response to antibiotics, sterol anabolism, secretion, membrane transport, and homeostasis. It localises to the fungal-type vacuole, mitochondrial inner membrane, and plasmalemma. Phenotypic associations include altered vacuolar morphology and distribution, decreased hypoosmotic stress resistance, increased entry into G0 phase, decreased anaerobic growth, and abnormal cell cycle progression. The gene is also linked to the related gene TLC1.