KIN1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G11431, designated KIN1 on chromosome 2 of Fusarium graminearum PH-1, encodes a protein serine/threonine kinase with histone H3S10 kinase, calcium/calmodulin-dependent kinase, and cyclin-dependent kinase activities, and binds calmodulin and ATP. The gene is associated with the regulation of mitotic and meiotic cell cycle processes, including spindle assembly checkpoint control, chromosome segregation, cytokinesis site selection, and kinetochore microtubule attachment repair. KIN1 is also linked to the upregulation of spore germination and localizes to the kinetochore microtubule, spindle midzone, CPC complex, and CDK holoenzyme. Studies of related genes in other species connect the family to calcium/calmodulin-dependent protein kinase activity and have been linked to fusarium ear blight in Triticum, though pathogenicity effects remain unconfirmed for this specific gene.