SSK1 — Fusarium graminearum PH-1

Summary

FgSSK1 (FGRAMPH1_01G11255) on chromosome 2 of Fusarium graminearum PH-1 encodes a protein with a two-component system histidine kinase domain, a signal transduction response regulator receiver domain, and a CheY-like superfamily domain. The gene is associated with histidine kinase activity, phosphorelay sensor kinase activity, protein kinase activator activity, phosphorelay response regulator activity, and ATP binding. It is linked to histidyl-aspartyl phosphorelay, osmolarity sensing via the two-component system, activation of the p38 cascade, the cellular HOG response, osmotic response, regulation of filamentous growth in response to neutral pH, starvation, and biotic stimuli, regulation of cellular response to oxidative stress, immune evasion, negative regulation of mitotic entry, and responses to farnesol and heat. The encoded protein localises to the membrane, cytoplasm, cell division site, and the Mcs4 RR-MAPKKK complex. Studies of related genes in other species link the family to virulence, pathogenicity, and oxidative stress response.