BD — Fusarium graminearum PH-1

Summary

FgBD (FGRAMPH1_01G10899) on chromosome 2 of Fusarium graminearum PH-1 encodes a small GTPase of the Ras-type family, possessing GTPase activity, GTP binding, and G protein activity. The gene is associated with Ras protein signal transduction, small GTPase-mediated signal transduction, regulation of conidium formation, spore germination, hyphal growth, sexual reproduction, cell polarization, and maintenance of protein location. It localizes to the plasma membrane, incipient cellular bud site, cellular bud neck, vacuolar membrane, and cell division site. Phenotypic associations link FgBD to decreased vacuolar transport rate, absent bipolar budding, decreased redox state, increased mating-type switching, decreased entry into G0, absent osmotic and oxidative stress resistance, and decreased budding rate. Related genes in other species link the family to reduced virulence and oxidative stress response.