LSB1 — Fusarium graminearum PH-1

Summary

FgLSB1 (FGRAMPH1_01G10991) on chromosome 2 of Fusarium graminearum PH-1 encodes a protein containing STAM and SH3 domains with F-actin binding activity. The gene is associated with regulation of actin polymerization, actin cytoskeleton organization, cytokinesis, and endocytosis, and its product localizes to the cortical actin cytoskeleton, F-actin, sites of polarized growth, and the cell cortex. Phenotypic associations include decreased cytokinesis rate, absent endocytosis, abnormal autophagy, prion formation and inheritance defects, absent innate thermotolerance, decreased bipolar budding, abnormal nuclear transport, decreased pexophagy, altered redox state, abnormal mitochondrial distribution, arrested or increased vegetative growth, decreased or absent pseudohyphal growth, delayed G1 cell cycle progression, and decreased spore germination.