ABCA — Fusarium graminearum PH-1

Summary

FgABCA (FGRAMPH1_01G10937) on chromosome 2 of Fusarium graminearum PH-1 encodes an ATP-binding cassette (ABC) transporter of the (PDR/CDR) subfamily, possessing ABC-type xenobiotic transporter activity, ATP-coupled transmembrane transporter activity, and ATP hydrolase activity. The protein localises to the plasma membrane and is associated with xenobiotic detoxification via transmembrane export, response to antibiotics and xenobiotic stimuli, cellular monoatomic cation homeostasis, toxin anabolism, DNA repair, and seed germination. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death rate, delayed mitophagy, and altered nutrient uptake, cell cycle progression, and pseudohyphal growth. Related genes in other species link the family to multidrug resistance and cellular detoxification processes.