EMI2 — Fusarium graminearum PH-1

Summary

FgEMI2 (FGRAMPH1_01G10791) on chromosome 2 of Fusarium graminearum PH-1 encodes a hexokinase with glucosamine kinase, mannokinase, glucokinase and fructokinase activities, and binds ATP and D-glucose. The protein localises to mitochondria and the cytosol. FgEMI2 is associated with glycolysis, glucose 6-phosphate metabolism, fructose and mannose metabolism, cell glucose homeostasis, fructose uptake, sexual reproduction, detoxification and systemic acquired resistance. Phenotypic associations include abnormal pheromone production, delayed chromosome segregation and protein modification, increased polyploidy, absent budding and endocytosis, decreased cytokinesis, abnormal meiosis and nuclear transport, altered fermentative and respiratory metabolism, and decreased G2 cell-cycle duration. Studies of related genes in other species link the family to virulence and oxidative stress response.