SOD1 — Fusarium graminearum PH-1

Summary

FgSOD1 (FGRAMPH1_01G10657) on chromosome 2 of Fusarium graminearum PH-1 encodes a copper-zinc superoxide dismutase, a Cu/Zn-binding oxidoreductase that acts on sulphur-group donors with oxygen as acceptor. The gene is associated with superoxide metabolism, detoxification, cell redox homeostasis, and cellular responses to oxidative stress and iron starvation. It is linked to hyphal growth, fungal-type cell wall organization, protein stabilization, and positive regulation of RNA polymerase II transcription. Localization evidence connects the product to the cytoplasm, nucleus, mitochondrial envelope lumen, and extracellular. Phenotypic associations include decreased spore germination, increased necrotic cell death, absent oxidative stress resistance, abnormal vacuolar distribution, and altered cell cycle progression through G1/S and G2/M transitions. Related genes in other species link the family to oxidative stress response and virulence.