OS-5 — Fusarium graminearum PH-1

Summary

FgOS-5 (FGRAMPH1_01G10579) on chromosome 2 of Fusarium graminearum PH-1 encodes a protein with serine/threonine kinase, dual-specificity protein kinase, MAPKK, and MAP kinase scaffold activities, and is associated with the NatB complex. The gene is associated with conidium germination, regulation of ascospore formation, positive regulation of appressorium formation, the cell integrity MAPK cascade, the pheromone response MAPK cascade, the osmosensory signaling pathway via Sho1, and the cellular HOG response. It is also linked to sexual reproduction, filamentous growth, invasive growth under glucose limitation, actin filament organization, and cell wall organization. Phenotypic associations include increased sporulation, altered cell cycle progression, increased freeze-thaw resistance, increased adhesion, and increased anaerobic growth. Studies of related genes in other species link the family to hyperosmotic stress resistance, loss of pathogenicity, and reduced virulence.