CFR1 — Fusarium graminearum PH-1

Summary

FgCFR1 (FGRAMPH1_01G10489) on chromosome 2 of Fusarium graminearum PH-1 encodes a protein with a CHS_Export/Cell_Fusion_Reg domain and BRCT domains, and is annotated with protein dimerization activity, small GTPase binding, and protein binding, bridging. The gene is associated with exomer complex and Golgi localisation, and with biological processes including cellular bud site selection, ascospore wall assembly, conjugation with cellular fusion, chitin anabolism and breakdown, glycogen metabolism, and TGN-to-endosome and Golgi-to-plasma membrane transport. Phenotypic associations include absent cell fusion and biofilm formation, abnormal bipolar budding and shmoo formation, decreased hyperosmotic stress resistance, increased polyploidy, delayed nuclear fusion during mating, and abnormal spore wall formation. Related genes in other species are linked to calcium sensitivity, protein content, and oxidative stress response.