MST2 — Fusarium graminearum PH-1

Summary

FgMST2 (FGRAMPH1_01G10071) on chromosome 2 of Fusarium graminearum PH-1 encodes a MYST-family histone acetyltransferase with multiple transferase activities, including histone H3K4, H3K14, H4K12, peptide butyryltransferase, crotonyltransferase and 2-hydroxyisobutyryltransferase activities. The product contains zinc-finger and PHD domains, binds chromatin and zinc, and localises to the NuA3a, Piccolo and TIP60 histone acetyltransferase complexes, chromatin, the nucleus and sites of DNA double-strand breaks. FgMST2 is associated with perithecium formation, positive regulation of triglyceride biosynthesis, spermidine anabolism, heterochromatin boundary formation, rDNA heterochromatin assembly, DNA repair-dependent chromatin remodelling, regulation of secondary metabolite biosynthesis, and both positive and negative regulation of gene expression. Studies of related genes in other species link the family to reduced virulence and lethality.