AREA — Fusarium graminearum PH-1

Summary

FgAREA (FGRAMPH1_01G10439) on chromosome 2 of Fusarium graminearum PH-1 encodes a GATA transcription factor with DNA-binding and both repressor and activator activities for RNA polymerase II. It is associated with nitrogen utilization, nitrate assimilation, regulation of arginine breakdown, secondary metabolism, mycotoxin anabolism, pH reduction, chromatin modeling, and transcriptional regulation. The gene is linked to numerous phenotypes including abnormal spore germination, increased hydrostatic pressure and X-ray resistance, increased entry into G0 phase, increased survival in stationary phase, increased pseudohyphal growth, increased osmotic stress resistance, decreased apoptosis, and altered autophagy and pexophagy. It localizes to the nucleus, cytoplasm, cytosol, and cell division site. Related genes in other species are linked to nitrate transport, nitrogen content, oxidative stress response, and altered virulence.