DBF2 — Fusarium graminearum PH-1

Summary

FgDBF2 (FGRAMPH1_01G10441) on chromosome 2 of Fusarium graminearum PH-1 encodes a serine/threonine protein kinase belonging to the AGC kinase family. The gene is associated with salicylic acid signaling pathways, systemic acquired resistance, and regulation of filamentous growth and primary cell septum biogenesis. It is linked to mitotic cytokinesis checkpoint control, actomyosin organization, lipid raft organization, and protein secretion regulation. The encoded protein localizes to the spindle, actomyosin contractile ring, hyphal tip, and spindle pole body. Phenotypic associations include absent septum formation, delayed chromosome segregation, abnormal cell cycle progression, decreased lifespan, and abnormal mating type switching. Studies of related genes in other species link the family to reduced virulence and the Sid2-Mob1 complex, with further connections to fusarium ear blight.