ABCA — Fusarium graminearum PH-1

Summary

FgABCA (FGRAMPH1_01G09633) on chromosome 2 of Fusarium graminearum PH-1 encodes an ABC transporter of the PDR/CDR subfamily, possessing ATP hydrolase and ATP-binding activities. This gene is associated with extracellular transport, seed germination, zearalenone biosynthetic process, response to toxic substances, xenobiotic detoxification via transmembrane export across the plasma membrane, detoxification, hypersensitivity, and DNA repair. The product localizes to the vacuolar membrane, plasma membrane, and membrane. FgABCA is associated with abnormal small molecule transport, increased sporulation rate, decreased cell death rate, and altered vacuolar distribution and transport. Studies of related genes in other species connect the family to plant height, leaf number, root length, drought tolerance, protein and phosphate content, oxidative stress response, and reduced virulence, as well as associations with fusarium head blight in wheat and barley.