ABCA — Fusarium graminearum PH-1

Summary

FgABCA (FGRAMPH1_01G08949) on chromosome 2 of Fusarium graminearum PH-1 encodes an ABC transporter of the PDR/CDR subfamily, possessing ATP hydrolase activity and ATP binding. The protein localises to the plasma membrane and is associated with extracellular transport, detoxification, toxin anabolism, hypersensitivity, DNA repair, and seed germination. Phenotypic associations link the gene to abnormal small molecule transport, increased sporulation, altered vacuolar distribution and transport, decreased cell death, delayed mitophagy, and aberrant cell cycle progression, pseudohyphal growth, and shmoo formation. It is also connected to nutrient uptake, endocytosis, and fermentative growth. Related genes in other species link the family to multidrug resistance, while sequence similarity extends associations to traits such as drought tolerance, plant height, and oxidative stress response in other species.