ACH1 — Fusarium graminearum PH-1

Summary

FgACH1 (FGRAMPH1_01G09513) on chromosome 2 of Fusarium graminearum PH-1 encodes a protein with acetyl-CoA hydrolase and acetate CoA-transferase activities, belonging to the ActCoA_hydro_N and acetyl-CoA hydrolase C-terminal domain families. The gene is associated with acetate metabolism, cellular response to basic pH, fatty acid anabolism, and sexual reproduction, with the product localizing to both mitochondria and cytosol. Phenotypic associations link FgACH1 to increased cell cycle progression through G2/M, increased nutrient and carbon source utilization, decreased apoptosis, and altered autophagy-related processes including absent late nucleophagy, decreased ribophagy, mitophagy, and reticulophagy, as well as absent pexophagy and protein secretion. The gene is also connected to increased flocculation and prion formation, decreased vacuolar transport and pseudohyphal growth, and abnormal protein accumulation. Studies of related genes in other species further associate it with abnormal carbon source utilization and decreased acid pH resistance.