TOR — Fusarium graminearum PH-1

Summary

FgTOR (FGRAMPH1_01G09193) on chromosome 2 of Fusarium graminearum PH-1 encodes a protein with serine/threonine-protein kinase activity, histone H2A kinase activity, pre-rRNA binding, and protein complex binding. It contains FRB, FAT, FATC, PI3/4-kinase catalytic, and HEAT repeat domains. The gene is associated with TORC1 and TORC2 signaling, energy homeostasis, DNA damage response, regulation of cell cycle transitions, and positive regulation of cytoplasmic translation and ribosomal protein gene transcription. FgTOR is linked to TOR complex, ATR-ATRIP complex, and nucleolar chromatin localization. Phenotypic associations include abnormal cell cycle progression, absent sporulation efficiency, increased virulence, altered carbon and nitrogen source utilization, and defective alkaline pH resistance. Related genes in other species link the family to oxidative stress response, protein content, and turgor pressure.