tasA — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G08921, designated tasA on chromosome 2 of Fusarium graminearum PH-1, encodes a protein containing an HpcH-HpaI aldolase domain and a pyruvate kinase-like domain, with annotated 4-hydroxy-4-methyl-2-oxoglutarate aldolase and aldehyde-lyase activities, and metal binding. The gene is associated with nitrogen fixation, phosphate metabolism, and biofilm formation, and its product is localised to the cytoplasm. Studies of related genes in other species link the family to a putative macrophomate synthase and 4-hydroxy-2-oxovalerate aldolase activity (EC 4.1.3.17).