CI-1 — Fusarium graminearum PH-1

Summary

FgCI-1 (FGRAMPH1_01G08807) on chromosome 2 of Fusarium graminearum PH-1 encodes a cytochrome P450 monooxygenase with heme binding, iron binding, and oxidoreductase activity acting on paired donors with incorporation of molecular oxygen. The gene is associated with the biosynthesis of ergosterol, griseofulvin, cichorine, terpenoids, and secondary metabolites generally. It is linked to numerous cellular and developmental phenotypes, including decreased colony size, increased cell death, arrested vegetative growth, abnormal autophagy, decreased meiosis, abnormal plasma membrane and cytoskeleton morphology, and increased budding. The encoded protein localizes to membranes. Studies of related genes in other species link the family to potassium concentration and acid sensitivity, though these associations are not established for FgCI-1 itself.