ABCA — Fusarium graminearum PH-1

Summary

FgABCA (FGRAMPH1_01G08743) on chromosome 1 of Fusarium graminearum PH-1 encodes an ATP-binding cassette (ABC) transporter of the (PDR/CDR) subfamily, possessing ATP hydrolase activity and ATP-coupled transmembrane transporter activity. The protein localises to the plasma membrane and is associated with xenobiotic detoxification via transmembrane export, response to antibiotics, toxin anabolism, and extracellular transport. It has also been linked to seed germination, DNA repair, and hypersensitivity. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, altered vacuolar distribution and transport, decreased cell death rate, delayed exit from stationary phase, and abnormal pseudohyphal growth, bipolar budding, and shmoo formation. Related genes in other species link the family to multidrug resistance and stress responses.