GRX3 — Fusarium graminearum PH-1

Summary

FgGRX3 (GRX3) on chromosome 1 of Fusarium graminearum PH-1 encodes a monothiol glutaredoxin with disulfide oxidoreductase, glutathione disulfide oxidoreductase, protein-disulfide reductase, and protein sequestering activities, and binds 2Fe-2S clusters and metals. The gene is associated with 4Fe-4S and 2Fe-2S cluster assembly, deubiquitination, cellular iron ion homeostasis, nitric oxide storage, positive regulation of transcription by RNA polymerase II, and general homeostasis. Its product localizes to the mitochondrial lumen, mitochondria, cytoplasm, cytosol, and nucleus. FgGRX3 is linked to numerous phenotypes including abnormal colony color, delayed pexophagy, decreased cell size at the G1 checkpoint, arrested S-phase cell cycle progression, decreased bipolar budding, decreased chitin deposition, increased meiotic recombination, increased mitochondrial rho- mutation frequency, decreased utilization of iron sources, and absent mating response. Related genes in other species are linked to oxidative stress response and phosphate content.