GYP1 — Fusarium graminearum PH-1

Summary

FgGYP1 (FGRAMPH1_01G07703) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein containing a Rab-GAP TBC domain and is annotated with GTPase activator (GAP) activity and 14-3-3 protein binding. The gene is associated with intracellular protein transport, vesicle transport, and localisation to the Golgi stack, Golgi complex, cytoplasm, cytosol, and nucleus. Phenotypic associations include decreased intracellular transport, cell cycle progression, and nucleophagy; abnormal Golgi morphology, vesicle distribution, endocytosis, and protein secretion; increased nutrient uptake and ionic stress resistance; and altered budding patterns, chitin deposition, and UV resistance. The gene is linked to the yeast GYP1 orthologue and interacts with COG complex components and ARL3. Related genes in other species connect it to vesicle trafficking.