NOT3 — Fusarium graminearum PH-1

Summary

FgNOT3 (FGRAMPH1_01G07891) on chromosome 1 of Fusarium graminearum PH-1 encodes a CCR4-NOT complex subunit belonging to the NOT2/3/5 family, with conserved Not_N and CCR4-NOT_su3/5 domains. The gene is associated with mRNA poly(A) tail shortening, transcription regulation by RNA polymerase II, signal transduction, asexual sporulation, spore germination, filamentous growth, biofilm formation, and cell-substrate adhesion. It localizes to the CCR4-NOT core complex, P-bodies, cytosol, and nucleus. Phenotypic associations include absent exponential-phase growth, delayed exit from G0, decreased S-phase progression, increased aneuploidy and RNA modification, abnormal autophagy and pseudohyphal growth, increased X-ray resistance, and decreased anaerobic and fermentative growth. Studies of related genes in other species link the family to reduced virulence and associations with fusarium head blight.